Zirconia is a non-silica-based ceramic which will not respond to a traditional pretreatment method such as, hydrofluoric acid-etching of the internal surface. Micro-mechanical retention achieved through sandblasting and chemical bonding through adhesion (ex. MDP) are key factors for successful zirconia bonding.

PANAVIA™ V5 and PANAVIA™ SA Cement Universal, which both include the MDP adhesive monomer, have high bond strength and durability to zirconia.